Journal article
Transgenerational programming of fetal nephron deficits and sex-specific adult hypertension in rats
LA Gallo, M Tran, LA Cullen-Mcewen, KM Denton, AJ Jefferies, KM Moritz, ME Wlodek
Reproduction Fertility and Development | Published : 2014
DOI: 10.1071/RD13133
Abstract
A developmental insult that restricts growth in the first generation has the potential to program disease in subsequent generations. The aim of this study was to ascertain transgenerational growth and cardio-renal effects, via the maternal line, in a rat model of utero-placental insufficiency. Bilateral uterine vessel ligation or sham surgery (offspring termed first generation; F1 Restricted and Control, respectively) was performed in WKY rats. F1 Restricted and Control females were mated with normal males to produce second generation (F2) offspring (Restricted and Control) studied from fetal (embryonic Day 20) to adult (12 months) life. F2 Restricted male and female fetuses had reduced (P<0..
View full abstractGrants
Funding Acknowledgements
The authors acknowledge the technical assistance of Kerryn T Westcott. This work was funded by the National Health and Medical Research Council of Australia (grant #400004), Heart Foundation of Australia (G 08M 3698) and the March of Dimes Birth Defects Foundation, USA ( grant #6-FY08-269). L. A. G. was supported by a Heart Foundation Biomedical Scholarship (Australia).